Unlike creams, the ViruLite delivers multiple cold sore treatments which means you can rely on this treatment to be there when you need it. Clinically proven to shorten time to heal so you'll be back to yourself - FAST ViruLite only has to be used 3 times a day for 2 days so forget checking the clock to see if its time to apply yet another messy dose of cream or ointment.
Please remove the safety seal on the battery before use. It needs battery to operate however the safety seal must be removed first. Frequently bought together. Add both to Cart Add both to List. FREE Shipping. Sold by SportingDoc and ships from Amazon Fulfillment.
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Please try your search again later. Product Description. How it works The virulite device emits a light that's invisible to the human eye. Important information Legal Disclaimer Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
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Short story - I've suffered from cold sores since I was a kid, so for nearly 30 years. I bought this product in an act of desperation during the worst outbreak of my life last year. I've always approached cold sores through "prevention" rather than "treatment" because once they're there So, I started keeping this light in my purse.
Whenever I got even a hint of a tingle - could have just been an itchy lip - I pulled this thing out and did the 3 minute treatment.
It beeps to start and when finished, so you know when you're good to go. I swear this thing helped keep what would have turned into sores at bay. Nipped them right in the bud when used at the first tingle and then every few hours that day out of paranoia. It runs on a 9V battery that seems to last months with irregular usage. Keep batteries at home because goodness knows it's going to run out as soon as you don't need it to.
The normally bright green light turns very dull and the beeps aren't as loud, so you'll be clued in when you need to change them. One managed to sneak up on me during the night recently and I was able to really put this thing to the test. The results are as follows. First sign of the tingle - is it a pimple? Better safe than sorry. Whipped this light out, did the treatment. Looked in the mirror, low and behold, there are a few tiny, tiny blisters in the bottom left corner of my mouth.
Cold sore confirmed. For the next three to four days, I used the light every two hours that I was awake. As you can see in the photos, the sore never did blister up beyond its initial appearance.
This light stopped it before it could really get started. If you've dealt with cold sores, you know that those pictures are much preferable to a full blown sore at day two or three. There was a problem completing your request. Please try your search again later.
From the manufacturer. At A Glance Perfect size for the office, your next party, or to stock up your fridge Zero calories per can Exhilarates and quenches its a one of a kind taste Experience the crisp, bold lemon lime flavor. Carbonated Soft Drink. Legal Disclaimer Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
See questions and answers. Customer reviews. How are ratings calculated? Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzes reviews to verify trustworthiness. Top reviews Most recent Top reviews. Top reviews from the United States. There was a problem filtering reviews right now.
Please try again later. Verified Purchase. Tasted like Mountain Dew, and there were no spills, dents, or anything wrong with the package.
What can I say, I love me some dew. I needed more, this presented a very helpful option in a pinch, but not something I would do all the time based on the added delivery charge fees, etc. Anyways, do the dew! I absolutely love Mt Dew. Best citrus style soft drink hands down. I start my day with a ice cold 12oz Can. Everyday and then mostly all day. But most of all it quenches even the meanest of thirsts!!! Wonderful pop! A specific gravity reagent composition including the molybdate-dye complex as described above can be used in dry phase, test pad assays for specific gravity.
The dry phase, test pad assay for specific gravity that utilizes the specific gravity reagent composition is performed in accordance with methods well known in the art. In general, the assay for specific gravity is performed by contacting the urine or other test sample with an analyte detection device that includes the specific gravity reagent composition. The analyte detection device can be dipped into the test sample, or the test sample can be applied to the analyte detection device dropwise.
The resulting change in color of the analyte detection device reveals the specific gravity of the test sample; and, if so designed, the resulting color transition can be compared to a standardized color chart to provide a measurement of the specific gravity of the urine or test sample. Typically, the analyte detection device is a test strip impregnated with a reagent composition, designed either as a single pad test strip to assay only for a single analyte or as a multiple pad test strip to assay for several analytes simultaneously.
For either type of reagent impregnated test strip, the test strip includes a support strip, or handle, normally constructed from a hydrophobic plastic, and a reagent test pad, comprising a bibulous or non-bibulous carrier matrix. In general, the carrier matrix is an absorbent material that allows the test sample to move, in response to capillary forces, through the matrix to contact the reagent composition and produce a detectable and measurable color transition. The carrier matrix can be any substance capable of incorporating the chemical reagents required to perform the assay of interest, as long as the carrier matrix is substantially inert with respect to the chemical reagents and does not contaminate the urine or other test samples either by test sample extraction of components comprising the carrier matrix or by appreciably altering the urine or test sample in a way to make the subsequent assays inconclusive, inaccurate or doubtful.
The expression "carrier matrix" refers to either bibulous or nonbibulous matrices that are insoluble in water and other physiological fluids and maintain their structural integrity when exposed to water and other physiological fluids. Suitable bibulous matrices include filter paper, sponge materials, cellulose, wood, woven and nonwoven fabrics and the like.
Nonbibulous matrices include glass fiber, polymeric films, and preformed or microporous membranes. Other suitable carrier matrices include hydrophilic inorganic powders, such as silica gel, alumina, diatomaceous earth and the like; argillaceous substances; cloth; hydrophilic natural polymeric materials, particularly cellulosic material, like cellulosic beads, and especially fiber-containing papers such as filter paper or chromatographic paper; synthetic or modified naturally-occuring polymers, such as cellulose acetate, polyvinyl chloride, polyacrylamide, polyacrylates, polyurethanes, crosslinked dextran, agarose, and other such crosslinked and noncrosslinked water-insoluble hydrophilic polymers.
Hydrophobic and non-absorptive substances are not suitable for use as the carrier matrix of the present invention.
The carrier matrix can be of different chemical compositions or a mixture of chemical compositions. The matrix also can vary in regards to smoothness and roughness combined with hardness and softness. However, in every instance, the carrier matrix must include a hydrophilic or absorptive material. The handle usually is formed from hydrophobic materials such as cellulose acetate, polyethylene, terephthalate, polycarbonate or polystyrene, and the carrier matrix is most advantageously constructed from bibulous filter paper or nonbibulous permeable polymeric films.
To achieve the full advantage of the present invention, the specific gravity reagent composition including the molybdate-dye complex is impregnated into a suitable carrier matrix and utilized in a dry phase test strip for the specific gravity assay of an aqueous test sample.
The method of the present invention affords an economical, accurate and reliable assay for the specific gravity of aqueous test samples that can be performed at home or in the laboratory. In addition, the method of the present invention allows the differentiation and measurement of test sample specific gravities that are very nearly identical, such as specific gravities that differ by only about 0.
In accordance with the method of the present invention, to perform a dry phase, test strip assay for specific gravity, the aqueous solution of the specific gravity reagent composition described above, including from about 0. The filter paper impregnated with the specific gravity reagent composition then is secured to an opaque or transparent hydrophobic plastic handle with double sided adhesive tape. The resulting test strip then was dipped into a fresh, uncentrifuged urine sample for a sufficient time to saturate the test pad with the sample.
After waiting a predetermined time, such as from about 1 min. The degree of color transition of the test pad reveals the specific gravity of the urine sample. In many cases simple visual observation of the test strip provides the desired information.
If more accurate information is required, a color chart bearing color spots corresponding to various standard specific gravities, can be prepared for the particular molybdate-dye complex specific gravity reagent composition used in the test strip. The resulting color of the test strip after contact with the urine sample then can be compared with the color spots on the chart to determine the specific gravity of the test sample. If a still more accurate determination is required, a spectrophotometer or colorimeter can be used to more precisely determine the degree of the color transition.
In addition, the dry phase, reagent strip assay can be made quantitative by employing spectrophotometric or colorimetric techniques, as opposed to visual techniques, in order to more reliably and more accurately measure the degree of color transition, and therefore more accurately measure the specific gravity of the test sample. As will be discussed more fully hereinafter, the ability of the specific gravity reagent composition to measure and differentiate between specific gravities that differ by as little as 0.
For example, according to present day methods, the accurate measurement of urine specific gravity requires a laboratory technique that is expensive and time-consuming. Accordingly, until the method of the present invention, no dry phase, test strip technique was available to accurately differentiate between and accurately measure urine specific gravities that differ by as little as approximately 0.
Therefore, in accordance with an important feature of the present invention, it has been demonstrated that by impregnating the specific gravity reagent composition including a molybdate-dye complex into a suitable carrier matrix, the accurate and reliable specific gravity assay of a urine sample can be achieved by using a dry phase test strip.
To show the new and unexpected results arising from using the specific gravity reagent composition of the present invention to differentiate and measure the specific gravity of a test sample, color space plots were made from specific gravity assays using dry phase test strips having a specific gravity reagent composition including a molybdate-dye complex impregnated into a filter paper matrix.
The color space plots were obtained by contacting standardized solutions of known specific gravities with the dry phase test strips including the specific gravity reagent composition impregnated into a filter paper carrier matrix. Theoretically, a color space difference of 1 unit is the smallest color difference the human eye can distinguish.
In general, the percent reflectance at each of the sixteen different wavelengths is multiplied by the intensity of the light at that wavelength.
These values then are multiplied by standard weighing functions for the colors red, green and blue, and finally added together. It should be noted that standardized urine solutions having different specific gravities, such as 1.
Initially, it was found that the prior art molybdate-dye complex used to assay urine for protein content was severely affected by the specific gravity of the urine sample. TABLE II summarizes a series of assays performed on standardized urine samples containing the same amount of albumin, but having differing ionic strengths and specific gravities due to the addition of sodium chloride.
Blue, and some gray 1. In Table II, the molybdate-dye indicator reagent was prepared by adding 75 mg of human albumin to a 25 ml volumetric flask, then filling the flask to a volume of 25 ml. The test strips then were dipped into a urine samples, each containing no albumin and each having different specific gravity and ionic strength due to the addition of sodium chloride.
It is readily observed in TABLE II that the molybdate-dye indicator reagent changed color from blue to grayish brown upon an ionic strength increase and a specific gravity increase from 1. These results demonstrate that the molybdate-dye complex reagent changes color in response to urine specific gravity and ionic strength. In addition, if the urine sample specific gravity is increased, but the ionic strength held constant, such as by adding glucose rather than sodium chloride to the urine sample, the color transitions observed in TABLE II due to an increase in specific gravity do not occur, showing that the molybdate-dye indicator reagent is more sensitive to the ionic strength changes of the urine sample than to the absolute specific gravity changes of the urine.
As demonstrated above, and as will be discussed more fully hereinafter, it was found that accurate urine specific gravity assays are achieved by using test strips incorporating the specific gravity reagent composition of the present invention because of the dependence of the color transition of the molybdate-dye complex on test sample ionic strength.
The results summarized in TABLE II for the molybdate-dye indicator reagent are quantified in TABLE III, wherein color space plots were obtained for assays of urine samples having different albumin concentrations and different specific gravities and ionic strengths to demonstrate the large effect of urine specific gravity on the color transition of the molybdate-dye indicator reagent.
However, TABLE III shows that using sodium chloride to increase the specific gravity of the urine sample containing no albumin also increases the ionic strength of the urine sample, and therefore, an accurate specific gravity assay using the method of the present invention results.
A careful examination of TABLE III shows that the color space differences obtained for test samples having an albumin content of essentially zero but differing ionic strengths and specific gravities exceeds 5 units, therefore showing that a visible color difference will be detected by the human assayer. In addition, it has been found that even if the urine sample has an increased amount of albumin, the color space difference due to specific gravity remains relatively constant.
Therefore, the amount of albumin present in the urine sample affects the specific gravity assay only minimally, and as will be discussed further hereinafter, the intentional addition of relatively large amounts of albumin to the specific gravity reagent composition effectively eliminates this minor interference. In accordance with the method and composition of the present invention, from TABLE III, using the molybdate-dye complex in a specific gravity reagent composition, all of the color space differences are well above the minimum human detectable limit of approximatley 5 units, therefore providing a specific gravity assay of the test sample.
The color space difference values are above approximately 5, therefore a color change is discernible by the human eye, and the assayer can differentiate between urine samples having specific gravities differing by as little as 0. TABLE IV, wherein the molybdate-dye indicator reagent used in the assays of TABLE II is used as the indicator to assay for the specific gravity of a test sample, shows color space differences of substantially less than 5 units as the albumin content of the test sample varies.
The results tabulated in TABLE V again show color space differences significantly less than the minimum visually detectable level of 5 units.
Such unexpected improvements provide an important and useful benefit over the prior art indicators used to assay for the specific gravity of test samples. As illustrated in the previous tables, the molybdate-dye complex included in the specific gravity reagent composition responds to the ionic strength of the test sample, is relatively unaffected by the nonionic components of the test sample, and therefore provides an accurate specific gravity assay.
It should be understood that those skilled in the art of designing test kits are able to design an optimal test strip incorporating a sufficient amount and a particularly effective molybdate-dye indicator specific gravity reagent composition to permit the differentiation and measurement of test sample specific gravities differing by as little as 0. Similarly, the method and composition of the present invention provide an accurate specific gravity assay regardless of varying amounts of test sample nonionic components, such as glucose or albumin, in amounts normally found in human fluids, as long as sufficient ionic components are present in the test sample to cause a color transition that can be correlated to test sample specific gravity.
In accordance with another important feature of the present invention, it has been found that full color development of test strips containing the molybdate-dye complex as the indicator in a specific gravity reagent composition occurs within about 1 min. Maximum color development occurs after about 2 min. However, acceptable and trustworthy specific gravity assay results are achieved when the test strip is examined for a color change about one minute after contact with the test sample.
Such a short time for full color development of the test strip is an additional advantage of the specific gravity reagent composition of the present invention over the molybdate-dye complex of the prior art composition used to assay for proteins that required approximately 10 minutes for maximum color development.
Therefore, test strips incorporating the molybdate-dye specific gravity reagent composition of the present invention can be used to obtain faster and more accurate specific gravity assays.
It should be noted that for all of the specific gravity assays summarized in the tables, the test strips incorporating the molybdate-dye complex reagent composition were examined for a response after a 2 minute contact time.
It also has been found that the color transition resulting from a test sample and molybdate-dye complex interaction is stable over time. It has been demonstrated that the change in color space difference between about one minute and about 2 minutes is relatively small, such that accurate assays will result about one minute after contact between the urine and the test strip incorporating the molybdate-dye specific gravity reagent composition.
Furthermore, it is seen that a urine sample containing varying amounts of albumin, or other nonionic components, may be accurately assayed by visual detection and measurement methods, because these nonionic urine components do not sufficiently interfere with the assay to generate a color space difference above the minimum required for differentiation by the human eye. Furthermore it has been found that a molar ratio of molybdate to dye of from about 3 to about 1 to about 1 to about 5 provides an indicator suitable for a specific gravity reagent composition to provide heightened sensitivity to the specific gravity of an aqueous test sample.
Overall, it has been shown that a molybdate-dye complex included in a specific gravity reagent composition impregnated into a suitable carrier matrix, such as filter paper, improves color differentiation between test samples having specific gravities differing by as little as 0. In addition to increased sensitivity over the prior art specific gravity assay methods, the method and composition of the present invention is not subject to detectable interferences from various nonionic test sample components, and provides full color development and accurate assay results in a relatively short time.
The method and composition of the present invention also allows visual differentiation of color transitions resulting from contact of the carrier matrix impregnated with the molybdate-dye complex specific gravity reagent composition between test samples having specific gravities differing by as low as 0.
Therefore, in accordance with an important feature of the present invention, more accurate and reliable assays for the specific gravity of urine and other liquid test samples can be performed by utilizing a molybdate-dye complex, a chelating agent and a sufficient amount of a protein in a specific gravity reagent composition.
The molybdate-dye indicator improves the color differentiation between test samples having nearly equal specific gravities and therefore improves assay sensitivity. The intentionally added protein overcomes and negates any interferences arising due to the protein content of the test sample. All rights reserved. Login Sign up. Search Expert Search Quick Search.
Composition and method of assaying aqueous liquids for specific gravity. Abstract of EP A new and improved composition and method of determining the specific gravity of an aqueous test sample.
The method includes using a test device comprising a carrier matrix incorporating a reagent composition capable of interacting with an aqueous test sample to produce a visually or instrumentally detectable and measurable response that correlates to the specific gravity of the aqueous test sample. The new and improved reagent composition, comprising a molybdate-dye complex indicator, such as a molybdate-pyrocatechol violet complex; a protein, such as albumin; a chelating agent, like tartaric acid; and, if necessary, a suitable buffer, is incorporated into a carrier matrix, like filter paper, to provide increased sensitivity to test sample specifically gravity and improved color differentiation between test samples having different specific gravities, thereby affording a more accurate and trustworthy specific gravity assay of an aqueous test sample, such as urine.
Click for automatic bibliography generation. The composition of claim 1 wherein the water-soluble molybdate is a molybdate selected from ammonium molybdate, sodium molybdate, bismuth molybdate, cadmium molybdate, calcium molybdate, lithium molybdate, magnesium molybdate, potassium molybdate, strontium molybdate, zinc molybdate alkylammonium or hydroxyalkylammonium molybdates, dialkylammonium or di hydroxyalkyl -ammonium molybdates, trialkylammonium or tri hydroxyalkyl ammonium molybdates and ammonium phosphomolybdates; or combinations thereof.
The composition of claim 1 wherein the polyhydroxybenzenesulfonephthalein dye or polyhydroxybenzenephthalein dye is selected from pyrocatechol violet, pyrogallol red, bromopyrogallol red, xylenol orange, pyrogallol phthalein and o-hydroxyhydroquinophthalein; or combinations thereof.
The composition of claim 1 wherein the chelating agent is selected from the free acid or the water-soluble salts of tartaric acid, oxalic acid, malonic acid, succinic acid, citric acid, ethylenediaminetetraacetic acid EDTA , gluconic acid, N- hydroxyethyl ethylenediaminetriacetic acie HEEDTA , nitrilotriacetic acid NTA , diethylenetriaminepentaacetic acid DTPA , aminotris methylene phosphonic acid , hydroxyethylidene diphosphonic acid, hexamethylenediaminetetra methylene phosphonate , ethylenediaminediacetic acid EDDA , iminodiacetic acid IDA , nitrilopropionic acid NTP , hydroxyethylimiodiacetic acid HIDA , pyrophosphoric acid, 1-hydroxyethane-1,1-diphosphonic acid, tripolyphosphoric acid, hexametaphosphoric acid and metaphosphoric acid; or combinations thereof.
A composition according to any of claims 1 - 5 for measuring the specific gravity of urine. A method of determining the specific gravity of an aqueous electrolyte-containing sample comprising: a contacting the aqueous sample with an analyte detection device comprising a reagent test pad containing the reagent composition of any one of claims 1 - 6; b examining the analyte detection device for a color transition in response to the electrolyte content of the aqueous test sample; and c correlating the color transition to the specific gravity of the aqueous test sample.
Apart from lactic acid and lactide, lactic acid O -carboxyanhydride "lac-OCA" , a five-membered cyclic compound has been used academically as well. This compound is more reactive than lactide, because its polymerization is driven by the loss of one equivalent of carbon dioxide per equivalent of lactic acid.
Water is not a co-product. The direct biosynthesis of PLA similar to the poly hydroxyalkanoate s has been reported as well. Another method devised is by contacting lactic acid with a zeolite. Due to the chiral nature of lactic acid, several distinct forms of polylactide exist: poly- L -lactide PLLA is the product resulting from polymerization of L , L -lactide also known as L -lactide.
PLA is soluble in solvents, hot benzene , tetrahydrofuran , and dioxane. In the latter case, PDLA acts as a nucleating agent , thereby increasing the crystallization rate [ citation needed ]. Several technologies such as annealing ,    adding nucleating agents, forming composites with fibers or nano-particles ,    chain extending   and introducing crosslink structures have been used to enhance the mechanical properties of PLA polymers.
Polylactic acid can be processed like most thermoplastics into fiber for example, using conventional melt spinning processes and film. PLA has similar mechanical properties to PETE polymer, but has a significantly lower maximum continuous use temperature. The tensile strength for 3-D printed PLA was previously determined. PLA can be solvent welded using dichloromethane. PLA is soluble in a range of organic solvents. PLA 3D printer filament dissolves when soaked in ethylacetate, making it a useful solvent for cleaning 3D printing extruder heads or removing PLA supports.
The boiling point of ethylacetate is low enough to also smooth PLA in a vapor chamber, similar to using acetone vapor to smooth ABS. Other safe solvents to use include propylene carbonate , which is safer than ethylacetate but is difficult to purchase commercially. Pyridine can also be used however this is less safe than ethylacetate and propylene carbonate.
It also has a distinct bad fish odor. PLA is used as a feedstock material in desktop fused filament fabrication 3D printers e. This is known as "lost PLA casting", a type of investment casting. PLA can degrade into innocuous lactic acid, so it is used as medical implants in the form of anchors, screws, plates, pins, rods, and as a mesh.
This gradual degradation is desirable for a support structure, because it gradually transfers the load to the body e. PLA can also be used as a decomposable packaging material, either cast, injection-molded, or spun. In the form of a film, it shrinks upon heating, allowing it to be used in shrink tunnels. It is useful for producing loose-fill packaging, compost bags, food packaging, and disposable tableware. In the form of fibers and nonwoven fabrics , PLA also has many potential uses, for example as upholstery , disposable garments, awnings , feminine hygiene products, and diapers.
Thanks to its bio-compatibility and biodegradability, PLA has also found ample interest as a polymeric scaffold for drug delivery purposes. Racemic and regular PLLA has a low glass transition temperature, which is undesirable. It has a wide range of applications, such as woven shirts ironability , microwavable trays, hot-fill applications and even engineering plastics in this case, the stereocomplex is blended with a rubber-like polymer such as ABS.
Such blends also have good form stability and visual transparency, making them useful for low-end packaging applications. Pure poly-L-lactic acid PLLA , on the other hand, is the main ingredient in Sculptra , a long-lasting facial volume enhancer, primarily used for treating lipoatrophy of cheeks.Feb 17, · Octodred Technological Illusions Vol. 2 Acid Fever Records MDMA Vinyl 12" 33 ⅓ RPM UK A total of were pressed Underground War Atomizer 5-T3LOE3T-8 Creeper.